CMM HyperCel

CMM HyperCel resin consists of a rigid cellulose matrix with flow characteristics compatible with the requirements of protein production at manufacturing scale.

Its proprietary ligand, containing both a primary amine group and a carboxyl group, provides the chromatography resin with both cation exchange and hydrophobic interaction properties. The flexibility of the ligand enables the separation of proteins across a wide range of isoelectric points and hydrophobicity levels, allowing multiple operating conditions to be used to separate target molecules from impurities.

Features and Benefits

• Unique selectivity
• High-capacity mixed-mode chromatography resin
• High recovery with low elution volumes
• Easy CIP procedures, NaOH stable

Applications

• Capture of monoclonal antibodies (mAbs), Fab fragments, and recombinant proteins from challenging feedstocks
• Separation of proteins with similar isoelectric points and/or differing hydrophobicity at low or high conductivity conditions