Anti-CHO HCP Detection Kit
- For CHO Host Cell Protein Detection
- Fully automated, walk-away HCP analysis
- Complete HCP results for 96 samples in as little as one hour
- Highly sensitive assays with CV values of 5–10%
- Detection sensitivity down to 0.5 ng/mL
- Categories: Protein Analysis | Biosensors and Kits |
Host cell proteins (HCPs) are contaminants found in biopharmaceuticals expressed in bacterial, yeast, or mammalian production cell lines. Among protein expression cell lines, Chinese Hamster Ovary (CHO) cells are the most widely used mammalian hosts for the industrial production of recombinant protein therapeutics.
However, biopharmaceutical manufacturing and purification processes often leave behind contaminating HCPs originating from CHO cells. These residual HCPs pose a significant risk by potentially reducing drug efficacy and causing adverse immunogenic reactions in patients. Therefore, the detection of residual HCP contaminants and the implementation of methods to reduce them to the lowest acceptable levels are critical aspects of drug safety and qualification.
Cygnus Technologies partnered in the co-development of the Octet® Anti-CHO HCP Kit for the quantification of residual HCPs. By combining the rapid, high-throughput protein analysis capabilities of the Octet platform with the broad HCP recognition and sensitivity of the industry-standard Cygnus 3G Anti-CHO HCP antibody, the kit provides scientists with a best-in-class solution for HCP analysis.